Enhanced Bioavailability of Atorvastatin Calcium from Stabilized Gastric Resident Formulation
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چکیده
منابع مشابه
Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives
Atorvastatin calcium, a lipid-lowering drug, is much less bioavailable because of reduced solubility in acidic media. Multiple-unit floating microcapsules of Atorvastatin calcium (ATC) were developed to expand the gastric residence time of the drug, as ATC has maximum rate of absorption in the upper GI tract. Floating microcapsules were prepared by Emulsion-solvent evaporation technique through...
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The main purpose of the present investigation is to enhance the solubility and bioavailability of poorly watersoluble atorvastatin calcium (ATR) through the self nanoemulsifying drug delivery system (SNEDDS).The components for self-nanoemulsion were identified by solubility studies and tendency for self-emulsification in various excipients. Sefsol 218, Cremophor RH 40 and Propylene glycol were ...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2011
ISSN: 1530-9932
DOI: 10.1208/s12249-011-9673-3